Cardinals vs Chargers Prediction, Picks & Odds | 13 Sep 2026

NFL Betting Preview: Cardinals vs Chargers

The Arizona Cardinals face the Los Angeles Chargers at SoFi Stadium, with kickoff scheduled for 16:25 on Sunday, September 13.

We’re going for a modest total when the Chargers clash with the Cardinals. Under 47.5 could be on the money and our prediction is currently available at odds of -118.

Arizona Cardinals went 3-14 in 2025 after ending the regular season with a 37-20 road loss against Los Angeles Rams at SoFi Stadium in Week 18. The Cards put up 317 yards, including 238 passing and 79 rushing yards. The offense picked up 17 first downs and scored two touchdowns.

Los Angeles Chargers posted an 11-6 regular-season record before advancing to the playoffs, where the Bolts suffered a 16-3 road loss against New England Patriots at Gillette Stadium in the Wild Card Round. The Chargers totaled 207 yards, including 120 through the air and 87 on the ground. They picked up 17 first downs while allowing New England to record 19.

Head-to-Head Statistics

It was a 17-15 win for the Cardinals at State Farm Stadium when they last played the Chargers.

Quarterbacks

Jacoby Brissett

217.5 Passing Yards

Over -114

Under -114

Justin Herbert

233.5 Passing Yards

Over -114

Under -114

Cardinals vs Chargers Prediction & Picks

The Cardinals vs Chargers betting tips feature sharp analysis across major markets, including a key match prediction, player prop bets, correct score guidance and a ready-made bet builder.

Game Prediction

When the teams line up in this NFL battle, we’re not sure that the total points will go over the line. Based on this pick, you can land odds of -118 for Under 47.5 and this looks worth taking.

The NFL predictions at Sportsgambler.com are always guided by the latest team news, injury updates and overall form. Once we've reviewed that, we dive into the most relevant stats to confidently recommend every pick.

Key Cardinals vs Chargers stats:

• The 47.5 line hasn’t been covered in 11 of the last 20 Cardinals games on the road.
• The 47.5 line hasn’t been covered in the last 5 Chargers games at home.
• The 47.5 line hasn’t been covered in 9 of the last 10 Chargers games.
• The 47.5 line hasn’t been covered in 15 of the last 20 Chargers games.

Under 47.5 Probability

According to the latest odds, there’s a 54.1% likelihood of our pick landing a return. After careful examination, our experts have this probability close to 60%. That means we are regarding it as a value wager.

If you’re going Under with your bet, then you can take the option to include this selection in a Bet Builder and get potentially bigger odds. Combine it with other picks.

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Our Game Prediction

Under 47.5 Points @ -118 Bet Now

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Disclosure: This preview contains affiliate links; we may earn a commission at no extra cost to you. T&Cs apply. We only recommend licensed and regulated operators. See our Editorial Policy. Pick odds and lines reflect the price available at the time of publication (Sep 11, 22:25). Live market odds are updated regularly and may differ. 18+ (or legal age) | Gamble Responsibly.

Player Prop Picks

Top Pick: Justin Herbert Under 233.5 Passing Yards -114

Justin Herbert (Chargers) is priced at -114 to record fewer than 233.5 passing yards. It’s reasonable to expect he may fall short, making the QB Passing Yards line appealing.

Latest Justin Herbert Player Prop Odds

Touchdown

Anytime

+450

First

+1900

Passing Yards

Over 233.5

-114

Under 233.5

-114

Rushing Yards

Over 19.5

-114

Under 19.5

-114

---

Jeremiyah Love Anytime TD +200

Jeremiyah Love (Cardinals) can be backed at +200 to hit the end zone. The Anytime Touchdown Scorer odds are appealing from all angles and we’re willing to take a chance on him.

Latest Jeremiyah Love Player Prop Odds

Touchdown

Anytime

+210

First

+1400

Receiving Yards

Over 15.5

-114

Under 15.5

-114

Rushing Yards

Over 31.5

-114

Under 31.5

-114

Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.

Correct Score Prediction

Cardinals 14 - 28 Chargers

The Chargers to win by a 28-14 scoreline could be worth a chance. There’s a massive potential return if you can land this bet on the money and it should provide some entertainment.

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Cardinals vs Chargers Odds

The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.

With an estimated 83% chance of winning, the sportsbooks are taking no chances with their -500 betting odds about Los Angeles Chargers triumphing in this game. At +385, Arizona Cardinals are regarded as having a lower probability of winning.

The spread is 8.5 and the total points line is currently 47.5. NFL fans regularly enjoy the opportunity to bet on the Totals. If you fancy Under 47.5, then the odds are -118.

Take a well-rounded approach when placing your bets. The top NFL betting sites are packed with team props and game lines, so focus on finding the selection that reflects your read on the matchup.

Moneyline

Cardinals

+385

Chargers

-500

Point Spread

Cardinals +8.5

-105

Chargers -8.5

-115

Total Points

Under 47.5

-118

Over 47.5

-104

Omarion Hampton is available at -149 when it comes to Anytime Touchdown Scorer. The favorite is now priced at odds of +440 to score the first TD.

Touchdown

Omarion Hampton (Chargers)

First TD

+440

Anytime TD

-149

Ladd McConkey (Chargers)

First TD

+750

Anytime TD

+135

Quentin Johnston (Chargers)

First TD

+750

Anytime TD

+135

Tyler Allgeier (Cardinals)

First TD

+1300

Anytime TD

+240

Jeremiyah Love (Cardinals)

First TD

+1400

Anytime TD

+210

Trey McBride (Cardinals)

First TD

+1400

Anytime TD

+200

Tre Harris (Chargers)

First TD

+1500

Anytime TD

+300

Marvin Harrison Jr. (Cardinals)

First TD

+1700

Anytime TD

+260

Charlie Kolar (Chargers)

First TD

+1900

Anytime TD

+360

Justin Herbert (Chargers)

First TD

+1900

Anytime TD

+450

Michael Wilson (Cardinals)

First TD

+2000

Anytime TD

+330

Kimani Vidal (Chargers)

First TD

+2000

Anytime TD

+350

David Njoku (Chargers)

First TD

+2200

Anytime TD

+480

Keaton Mitchell (Chargers)

First TD

+2200

Anytime TD

+430

Oronde Gadsden II (Chargers)

First TD

+2500

Anytime TD

+500

Kendrick Bourne (Cardinals)

First TD

+3500

Anytime TD

+650

KeAndre Lambert-Smith (Chargers)

First TD

+3500

Anytime TD

+800

Brenen Thompson (Chargers)

First TD

+3500

Anytime TD

+800

Jacoby Brissett (Cardinals)

First TD

+4500

Anytime TD

+950

Elijah Higgins (Cardinals)

First TD

+5000

Anytime TD

+1000

Simi Fehoko (Cardinals)

First TD

+8000

Anytime TD

+1600

Derius Davis (Chargers)

First TD

+8000

Anytime TD

+2200

Hunter Long (Cardinals)

First TD

+10000

Anytime TD

+2200

Reggie Virgil (Cardinals)

First TD

+10000

Anytime TD

+2200

Devin Duvernay (Cardinals)

First TD

+10000

Anytime TD

+2500

Alec Ingold (Chargers)

First TD

+10000

Anytime TD

+3000

Bam Knight (Cardinals)

First TD

+10000

Anytime TD

+2200

Jalen Brooks (Cardinals)

First TD

+10000

Anytime TD

+2500

Receiving Yards

Ladd McConkey (Chargers)

Over 56.5

-114

Under 56.5

-114

Trey McBride (Cardinals)

Over 56.5

-114

Under 56.5

-114

Marvin Harrison Jr. (Cardinals)

Over 47.5

-114

Under 47.5

-114

Quentin Johnston (Chargers)

Over 42.5

-114

Under 42.5

-114

Michael Wilson (Cardinals)

Over 41.5

-114

Under 41.5

-114

Tre Harris (Chargers)

Over 26.5

-114

Under 26.5

-114

Kendrick Bourne (Cardinals)

Over 18.5

-114

Under 18.5

-114

Charlie Kolar (Chargers)

Over 17.5

-114

Under 17.5

-114

Jeremiyah Love (Cardinals)

Over 15.5

-114

Under 15.5

-114

Omarion Hampton (Chargers)

Over 12.5

-114

Under 12.5

-114

Rushing Yards

Omarion Hampton (Chargers)

Over 71.5

-114

Under 71.5

-114

Tyler Allgeier (Cardinals)

Over 34.5

-114

Under 34.5

-114

Jeremiyah Love (Cardinals)

Over 31.5

-114

Under 31.5

-114

Keaton Mitchell (Chargers)

Over 24.5

-114

Under 24.5

-114

Justin Herbert (Chargers)

Over 19.5

-114

Under 19.5

-114

Jacoby Brissett (Cardinals)

Over 10.5

-114

Under 10.5

-114

Passing Yards

Justin Herbert (Chargers)

Over 233.5

-114

Under 233.5

-114

Jacoby Brissett (Cardinals)

Over 217.5

-114

Under 217.5

-114

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Chargers Have Taken Seven Wins From Last Ten Home Outings

The Chargers own a 7-3 mark in their past 10 home games, averaging 24.90 points on offense and surrendering 20.60 on defense.

The Cardinals have lost five straight on the road. Arizona has two wins and eight losses in the last 10 games away from home, putting up 19.10 points per contest and giving up 26.80.

Last 10 Games		W-L	P	PF	PA	O47.5	U47.5
Chargers Home Stats		7-3	45.50	24.90	20.60	3	7
Cardinals Away Stats		2-8	45.90	19.10	26.80	5	5

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O47.5 = Games Over 47.5 Points
• U47.5 = Games Under 47.5 Points

Latest regular season and playoff games stats.

Arizona Cardinals Stats

Los Angeles Chargers Stats

Moneyline

• 1 win and 9 defeats in the last 10 games
• 2 wins and 8 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 7 wins and 3 defeats in the last 10 home games

Point Spread

• +9.5 Betting Line: Have covered the spread in 4 of the last 10 games
• +9.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -9.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -9.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 53.60 pts in the previous 10 games
• Game Totals on the Road: An average of 45.90 pts in the previous 10 games on the road
• Over 47.5: Covered in 7 of the previous 10 games
• Over 47.5 on the Road: Covered in 5 of the previous 10 games on the road
• Team Totals: Have scored an average of 20.20 pts and allowed 33.40 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 19.10 pts and allowed 26.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 36.60 pts in the previous 10 games
• Game Totals at Home: An average of 45.50 pts in the previous 10 home games
• Over 47.5: Covered in 1 of the previous 10 games
• Over 47.5 at Home: Covered in 3 of the previous 10 home games
• Team Totals: Have scored an average of 18.30 pts and allowed 18.30 pts in the last 10 games
• Team Totals at Home: Have scored an average of 24.90 pts and allowed 20.60 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 336.60 Yds. Allowed 373.10 Yds
• Rushing Yards: Gained 81.00 Yds. Allowed 145.20 Yds
• Passing Yards: Gained 255.60 Yds. Allowed 227.90 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 3.90 TD
• Rushing Touchdowns: Scored 0.40 TD. Allowed 1.30 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 2.30 TD
• Total 1st Downs: Picked up 19.90. Allowed 23.00
• Total Turnovers: Committed 1.30. Committed by opponents 1.20
• Total Penalties: Committed 6.10. Committed by opponents 4.50
• Penalty Yards: Lost 44.90 Yds. Gained 33.80 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 285.40 Yds. Allowed 285.50 Yds
• Rushing Yards: Gained 116.90 Yds. Allowed 103.80 Yds
• Passing Yards: Gained 168.50 Yds. Allowed 181.70 Yds
• Total Touchdowns: Scored 1.70 TD. Allowed 1.80 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.60 TD
• Passing Touchdowns: Scored 1.00 TD. Allowed 0.90 TD
• Total 1st Downs: Picked up 17.30. Allowed 16.50
• Total Turnovers: Committed 1.10. Committed by opponents 1.70
• Total Penalties: Committed 4.80. Committed by opponents 4.70
• Penalty Yards: Lost 38.20 Yds. Gained 41.10 Yds

Last 10 Games on the Road

• Total Yards: Gained 325.00 Yds. Allowed 348.90 Yds
• Rushing Yards: Gained 98.90 Yds. Allowed 122.00 Yds
• Passing Yards: Gained 226.10 Yds. Allowed 226.90 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 2.90 TD
• Rushing Touchdowns: Scored 0.30 TD. Allowed 1.10 TD
• Passing Touchdowns: Scored 1.90 TD. Allowed 1.50 TD
• Total 1st Downs: Picked up 20.10. Allowed 21.10
• Total Turnovers: Committed 1.10. Committed by opponents 0.80
• Total Penalties: Committed 5.50. Committed by opponents 5.80
• Penalty Yards: Lost 42.10 Yds. Gained 45.70 Yds

Last 10 Home Games

• Total Yards: Gained 355.50 Yds. Allowed 302.50 Yds
• Rushing Yards: Gained 127.90 Yds. Allowed 99.90 Yds
• Passing Yards: Gained 227.60 Yds. Allowed 202.60 Yds
• Total Touchdowns: Scored 2.60 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 21.80. Allowed 16.50
• Total Turnovers: Committed 1.30. Committed by opponents 1.30
• Total Penalties: Committed 5.70. Committed by opponents 6.70
• Penalty Yards: Lost 41.00 Yds. Gained 58.00 Yds

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