Oregon vs USC Prediction, Picks & Odds | 26 Sep 2026
College Football Betting Preview: Oregon vs USC
Oregon square off against USC at LA Memorial Coliseum, with kickoff scheduled for 19:30 on Saturday, September 26.
There’s some value on the spread and we like USC at +2.5. We’re very happy to take them with this advantage against Oregon at -100.
Oregon Ducks claimed a victory in their previous game. A 84-0 home win occurred against Portland State Vikings at Autzen Stadium.
USC Trojans got a fourth straight win in their last game. It was a 42-35 road triumph at SHI Stadium when meeting Rutgers Scarlet Knights.
Head-to-Head Statistics
Oregon won the last matchup between the pair. Enjoying a 42-27 triumph when facing USC at Autzen Stadium. In the past 4 H2H games, Oregon have won every time.
Quarterbacks
Dante Moore
Jayden Maiava
Oregon vs USC Prediction & Picks
Get the full betting picture for Oregon vs USC, including a key match prediction, our best correct score selection, top player prop picks and a ready-made bet builder.
Game Prediction
USC look easy to back at -100 considering they’ve been given a spread of +2.5. This looks a good number when squaring off in this college football battle.
The CFB handicappers at Sportsgambler.com start by analyzing recent form and staying on top of injury news before making any picks. From there, we interpret the story the stats are telling to help shape our predictions.
Key Oregon vs USC stats:
USC +2.5 Probability
If you go by the best sportsbooks, our pick has a 50% prospect of winning. Based on our in-depth research, our analysts calculate the actual probability to be 55-60%. It's therefore regarded as a value wager.
As a wagering alternative, you can choose to buy or sell points when it comes to your spread pick. Buy if you want a safer bet and sell to get more juice from the line.
Before placing a wager, see what betting offers are on the table. Our in-depth guide lists the top welcome bonuses right now.
Player Prop Picks
The odds for Dante Moore (Oregon) to end with fewer than 271.5 passing yards are -114. We're confident he’ll fall short of the QB Passing Yards line, so we're backing the Under.
Jamari Johnson (USC) is priced at -114 to finish with fewer than 41.5 receiving yards. It’s reasonable to expect he may fall short, making the Player Receiving Yards line appealing.
Pick odds and lines correct at publication. Live market odds are updated regularly and may differ. T&Cs apply. 18+ (or legal age) | Gamble Responsibly.
Same Game Parlay Picks
We’ve got a same game parlay with three options: USC +2.5, Under 61.5 points and Dante Moore (Oregon) to have Under 271.5 passing yards.
A same game parlay is an awesome way of cheering on different outcomes within the same football game. You can predict a number of outcomes and get bigger odds than a single wager. The odds can combine to great effect.
Correct Score Prediction
27
-
31
USC
Don’t pass up the opportunity to have a speculative bet on the Trojans to land a 31-27 win. We don’t think that there will be too much between the teams.
Oregon vs USC Odds
The odds and lines below are updated regularly and may differ from the prices shown in our picks, which are captured at the time of publication.
With the sportsbooks giving them a 63% probability of winning this college game, Oregon might be a popular parlay pick. That is reflected in their -169 Moneyline betting odds. USC are regarded as a long shot to win and you can currently back them at +140.
3.5 is the spread and 61.5 is the total points line. Football bettors regularly enjoy the opportunity to wager on the Totals. If you’re going for Under 61.5, this outcome can be backed at -110.
Whether you are wagering pre-game or in-game on college football, the top betting apps let you feast on a wide range of team props and game lines. The selections are practically endless, and it’s awesome to have so many options at your fingertips.
Receiving Yards
Rushing Yards
Passing Yards
USC Looking to Extend Strong Home Form
USC have ten wins and zero loss in the last 10 games at home, averaging 43.10 points scored and 18.10 points allowed.
Oregon have gone 8-2 across their last 10 games games on the road, scoring 29.40 points per contest and conceding 20.30.
When the teams last met at LA Memorial Coliseum, Oregon beat USC 31-24.
| Last 10 Games | W-L | P | PF | PA | O61.5 | U61.5 | |
|---|---|---|---|---|---|---|---|
 USC Home Stats |
10-0 | 61.20 | 43.10 | 18.10 | 5 | 5 | |
 Oregon Away Stats |
8-2 | 49.70 | 29.40 | 20.30 | 3 | 7 | |
- W-L = Wins-Losses
- P = Avg. Points
- PF = Avg. Points For
- PA = Avg. Points Against
- O61.5 = Games Over 61.5 Points
- U61.5 = Games Under 61.5 Points
Latest regular season and playoff games stats.
Oregon Ducks Stats
USC Stats
- 8 wins and 2 defeats in the last 10 games
- 8 wins and 2 defeats in the last 10 games on the road
- -2.5 Betting Line: Have covered the spread in 7 of the last 10 games
- -2.5 Betting Line on the Road: Have covered the spread in 7 of the last 10 games on the road
- +2.5 Betting Line: Have covered the spread in 8 of the last 10 games
- +2.5 Betting Line at Home: Have covered the spread in the last 10 home games
- Game Totals: An average of 59.90 pts in the previous 10 games
- Game Totals on the Road: An average of 49.70 pts in the previous 10 games on the road
- Over 61.5: Covered in 5 of the previous 10 games
- Over 61.5 on the Road: Covered in 3 of the previous 10 games on the road
- Team Totals: Have scored an average of 37.30 pts and allowed 22.60 pts in the last 10 games
- Team Totals on the Road: Have scored an average of 29.40 pts and allowed 20.30 pts in the last 10 games on the road
- Game Totals: An average of 56.80 pts in the previous 10 games
- Game Totals at Home: An average of 61.20 pts in the previous 10 home games
- Over 61.5: Covered in 4 of the previous 10 games
- Over 61.5 at Home: Covered in 5 of the previous 10 home games
- Team Totals: Have scored an average of 34.00 pts and allowed 22.80 pts in the last 10 games
- Team Totals at Home: Have scored an average of 43.10 pts and allowed 18.10 pts in the last 10 home games
| Big Ten | W | L | PF | PA | N. Pts | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|
Indiana
|
4 | 0 | 174 | 39 | 135 | 4-0 | 0-0 | 4W |
UCLA
|
3 | 0 | 125 | 72 | 53 | 2-0 | 1-0 | 3W |
|
USC
|
4 | 0 | 172 | 91 | 81 | 3-0 | 1-0 | 4W |
Michigan State
|
2 | 1 | 75 | 54 | 21 | 2-0 | 0-1 | 1L |
Wisconsin
|
2 | 1 | 103 | 60 | 43 | 2-0 | 0-1 | 2W |
|
Oregon
|
2 | 1 | 149 | 66 | 83 | 2-0 | 0-1 | 1W |
Ohio State
|
2 | 1 | 138 | 30 | 108 | 2-0 | 0-1 | 1W |
Minnesota
|
2 | 1 | 113 | 52 | 61 | 2-1 | 0-0 | 1W |
Maryland
|
2 | 1 | 126 | 49 | 77 | 1-1 | 1-0 | 1L |
Iowa
|
3 | 0 | 111 | 13 | 98 | 3-0 | 0-0 | 3W |
Illinois
|
2 | 1 | 117 | 64 | 53 | 2-1 | 0-0 | 1W |
Washington
|
3 | 0 | 88 | 40 | 48 | 3-0 | 0-0 | 3W |
Penn State
|
3 | 0 | 127 | 22 | 105 | 2-0 | 1-0 | 3W |
Nebraska
|
3 | 0 | 139 | 35 | 104 | 3-0 | 0-0 | 3W |
Michigan
|
3 | 0 | 82 | 39 | 43 | 3-0 | 0-0 | 3W |
Northwestern
|
2 | 1 | 98 | 54 | 44 | 2-0 | 0-1 | 1L |
Purdue
|
1 | 2 | 118 | 109 | 9 | 1-1 | 0-1 | 2L |
Rutgers
|
1 | 3 | 135 | 114 | 21 | 1-2 | 0-1 | 1W |
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